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Pure Appl. Chem., 2012, Vol. 84, No. 7, pp. 1587-1595

http://dx.doi.org/10.1351/PAC-CON-11-09-26

Published online 2012-04-07

Influence of the difluoromethylene group (CF2) on the conformation and properties of selected organic compounds

David O'Hagan*, Yi Wang, Maciej Skibinski and Alexandra M. Z. Slawin

EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK

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  • Li Lingchun, Wang Fei, Ni Chuanfa, Hu Jinbo: Synthesis of gem -Difluorocyclopropa(e)nes and O- , S- , N- , and P-Difluoromethylated Compounds with TMSCF2 Br. Angew. Chem. 2013, 125, 12616. <http://dx.doi.org/10.1002/ange.201306703>
  • Li Lingchun, Wang Fei, Ni Chuanfa, Hu Jinbo: Synthesis of gem -Difluorocyclopropa(e)nes and O- , S- , N- , and P-Difluoromethylated Compounds with TMSCF2 Br. Angew. Chem. Int. Ed. 2013, 52, 12390. <http://dx.doi.org/10.1002/anie.201306703>
  • O'Hagan David, Wang Yi, Skibinski Maciej, Slawin Alexandra M. Z.: ChemInform Abstract: Influence of the Difluoromethylene Group (CF2 ) on the Conformation and Properties of Selected Organic Compounds. ChemInform 2013, 44, no. <http://dx.doi.org/10.1002/chin.201310250>
  • Lin Xiaowei, Qing Feng-Ling: Palladium-Catalyzed Anti-Markovnikov Hydroalkylation of Homoallylic Alcohols Bearing β-Fluorines. Org. Lett. 2013, 15, 4478. <http://dx.doi.org/10.1021/ol402032a>
  • Chia Poh Wai, Bello Davide, Slawin Alexandra M. Z., O'Hagan David: Fluorinated 5- and 7-membered carbacycle motifs by reaction of difluorocarbene with acetylene ethers. Chem. Commun. 2013, 49, 2189. <http://dx.doi.org/10.1039/c3cc39066g>
  • Urbina-Blanco César A., Skibiński Maciej, O'Hagan David, Nolan Steven P.: Accelerating influence of the gem-difluoromethylene group in a ring-closing olefin metathesis reaction. A Thorpe–Ingold effect?. Chem. Commun. 2013, 49, 7201. <http://dx.doi.org/10.1039/c3cc44312d>
  • Skibiński Maciej, Urbina-Blanco César A., Slawin Alexandra M. Z., Nolan Steven P., O'Hagan David: Synthesis and structure of large difluoromethylene containing alicycles by ring closing metathesis (RCM). Org. Biomol. Chem. 2013, 11, 8209. <http://dx.doi.org/10.1039/c3ob42062k>