Pure and Applied Chemistry

Pure Appl. Chem., 2012, Vol. 84, No. 7, pp. 1543-1556

http://dx.doi.org/10.1351/PAC-CON-11-11-09

Published online 2012-06-07

Targeting neurodegenerative diseases: Drug discovery in a challenging arena

References

• 1. S. Saxena, P. Caroni. Neuron 71, 35 (2011). (http://dx.doi.org/10.1016/j.neuron.2011.06.031)
• 2. For a recent review, see: N. Herrmann, S. A. Chau, I. Kircanski, K. L. Lanctot. Drugs 71, 2031 (2011). (http://dx.doi.org/10.2165/11595870-000000000-00000)
• 3. X.-P. Wang, H.-L. Ding. Neurosci. Bull. 24, 105 (2008). (http://dx.doi.org/10.1007/s12264-008-0105-7)
• 4. A. Wimo, M. Prince. World Alzheimer Report 2010, Alzheimer’s Disease International, available online at: <http://www.alz.co.uk/research/files/WorldAlzheimerReport2010.pdf>.
• 5. G. M. Shanker, D. M. Walsh. Mol. Neurodegen. (2009). Available online at: <http://www.molecularneurodegeneration.com>.
• 6. For a recent review, see: A. D. Korczyn. Alzheimer’s Dementia 4, 176 (2008). (http://dx.doi.org/10.1016/j.jalz.2007.11.008)
• 7. K. G. Mawuenyega, W. Sigurnson, V. Ovod, L. Munsell, T. Kasten, J. C. Morris, K. E. Yarasheski, R. J. Bateman. Science 330, 1774 (2010). (http://dx.doi.org/10.1126/science.1197623)
• 8. N. Marks, M. J. Berg. Neurochem. Res. 35, 181 (2010). (http://dx.doi.org/10.1007/s11064-009-0054-1)
• 9. A. F. Kreft, R. Martone, A. Porte. J. Med. Chem. 52, 6169 (2009). (http://dx.doi.org/10.1021/jm900188z)
• 10. W.-H. Huang, R. Sheng, Y.-A. Hu. Curr. Med. Chem. 16, 1806 (2009). (http://dx.doi.org/10.2174/092986709788186174)
• 11. B. P. Imbimbo, I. Peretto. Curr. Opin. Invest. Drugs 10, 721 (2009).
• 12. Eli Lilly Press Release, 17 August 2010, accessed on 14 October 2011 at: <http://newsroom.lilly.com/releasedetail.cfm?ReleaseID=499794>.
• 13. S. C. Mayer, A. F. Kreft, B. Harrison, M. Abou-Gharbia, M. Antane, S. Aschmies, K. Atchison, M. Chlenov, D. C. Cole, T. Comery, G. Diamantidis, J. Ellingboe, K. Fan, R. Galante, C. Gonzales, D. M. Ho, M. E. Hoke, Y. Hu, D. Huryn, U. Jain, M. Jin, K. Kremer, D. Kubrak, M. Lin, P. Lu, R. Magolda, R. Martone, W. Moore, A. Oganesian, M. N. Pangalos, A. Porte, P. Reinhart, L. Resnick, D. R. Riddell, J. Sonnenberg-Reines, J. R. Stock, S.-C. Sun, E. Wagner, T. Wang, K. Woller, Z. Xu, M. M. Zaleska, J. Zeldis, M. Zhang, H. Zhou, J. S. Jacobsen. J. Med. Chem. 51, 7348 (2008). (http://dx.doi.org/10.1021/jm801252w)
• 14. A. Hall, R. L. Elliot, G. M. P. Giblin, I. Hussain, J. Musgrave, A. Naylor, R. Sasse, B. Smith. Bioorg. Med. Chem. Lett. 20, 1306 (2010). (http://dx.doi.org/10.1016/j.bmcl.2009.08.072)
• 15. W.-H. Huang, R. Sheng, H.-A. Hu. Curr. Med. Chem. 16, 1806 (2009). (http://dx.doi.org/10.2174/092986709788186174)
• 16. M. S. Malamas, J. Erdei, I. Gunawan, K. Barnes, M. Johnson, Y. Hui, J. Turner, Y. Hu, E. Wagner, K. Fan, A. Olland, J. Bard, A. J. Robichaud. J. Med. Chem. 52, 6314 (2009). (http://dx.doi.org/10.1021/jm9006752)
• 17. P. Wu, L. Brand. Anal. Biochem. 218, 1 (1994). (http://dx.doi.org/10.1006/abio.1994.1134)
• 18. I. Schechter, E. Ziv. Biol. Chem. 389, 313 (2008). (http://dx.doi.org/10.1515/BC.2008.025)
• 19. M. S. Malamas, J. Erdei, I. Gunawan, J. Turner, Y. Hu, E. Wagner, K. Fan, R. Chopra, A. Olland, J. Bard, S. Jacobsen, R. L. Magolda, M. Pangalos, A. J. Robichaud. J. Med. Chem. 53, 1146 (2010). (http://dx.doi.org/10.1021/jm901414e)
• 20. K. Hsiao, P. Chapman, S. Nilson, C. Eckman, Y. Harigaya, S. Younkin, F. Yang, G. Cole. Science 274, 99 (1996). (http://dx.doi.org/10.1126/science.274.5284.99)
• 21. T. A. Comery, R. L. Martone, S. Aschmies, K. P. Atchison, G. Diamantidis, X. Gong, H. Zhou, A. F. Kreft, M. N. Pangalos, J. Sonnenberg-Reines, J. S. Jacobsen, K. L. Marquis. J. Neurosci. 25, 8898 (2005). (http://dx.doi.org/10.1523/JNEUROSCI.2693-05.2005)
• 22. World Health Organization. “STEPwise approach to stroke surveillance”, accessed online on 14 October 2011 at: <http://www.who.int/chp/steps/stroke/en/index.html>.
• 23. H. P. Adams Jr., G. del Zoppo, J. J. Alberts, D. L. Bhatt, L. Brass, A. Furlan, R. L. Grubb, R. T. Higashida, E. C. Jauch, C. Kidwell, P. D. Lyden, L. B. Morgenstern, A. I. Qureshi, R. H. Rosenwasser, P. A. Scott, E. F. M. Wijdicks. Stroke 38, 1655 (2007). (http://dx.doi.org/10.1161/STROKEAHA.107.181486)
• 24. J. Kaur, Z. Zhao, G. M. Kline, E. H. Lao, A. M. Buchan. J. Cereb. Blood Flow Metab. 24, 945 (2004). (http://dx.doi.org/10.1097/01.WCB.0000137868.50767.E8)
• 25. V. E. O’Collins, M. R. Macleod, G. A. Donnan, L. L. Horky, B. H. van der Worp, D. W. Howells. Ann. Neurol. 59, 467 (2006). (http://dx.doi.org/10.1002/ana.20741)
• 26. H. T. Ghashghaei, C. Lai, E. S. Anton. Nat. Rev. Neurosci. 8, 141 (2007). (http://dx.doi.org/10.1038/nrn2074)
• 27. A. M. Enciu, M. I. Nicolescu, C. G. Manole, D. F. Muresanu, L. M. Popescu, B. O. Popescu. BMC Neurol. 11, 75 (2011). (http://dx.doi.org/10.1186/1471-2377-11-75)
• 28. G. Pyne-Geithman. Neurology 74, 352 (2010). (http://dx.doi.org/10.1212/WNL.0b013e3181cfc1a5)
• 29. M. M. Zaleska, M. L. T. Mercado, J. Chavez, G. Z. Feuerstein, M. N. Pangalos, A. Wood. Neuropharmacology 56, 329 (2009). (http://dx.doi.org/10.1016/j.neuropharm.2008.10.006)
• 30. C. Vezina, A. Kudelski, S. N. Sehgal. J. Antibiot. 28, 721 (1975). (http://dx.doi.org/10.7164/antibiotics.28.721)
• 31. S. N. Sehgal. Clin. Biochem. 31, 335 (1998). (http://dx.doi.org/10.1016/S0009-9120(98)00045-9)
• 32. N. Hay, N. Sonenberg. Genes Dev. 18, 1926 (2004). (http://dx.doi.org/10.1101/gad.1212704)
• 33. S. Wullschleger, R. Loewith, M. N. Hall. Cell 124, 471 (2006). (http://dx.doi.org/10.1016/j.cell.2006.01.016)
• 34. J. Choi, J. Chen, S. L. Schreiber, J. Clardy. Science 273, 239 (1996). (http://dx.doi.org/10.1126/science.273.5272.239)
• 35. W. E. Lyons, E. B. George, T. M. Dawson, J. P. Steiner, S. H. Snyder. Proc. Nat. Acad. Sci. USA 94, 3191 (1994). (http://dx.doi.org/10.1073/pnas.91.8.3191)
• 36. M. Y. Summers, M. Leighton, D. Liu, K. Pong, E. I. Graziani. J. Antibiot. 59, 184 (2006). (http://dx.doi.org/10.1038/ja.2006.26)
• 37. D. Liu, B. McIlvain, M. Fennell, J. Dunlop, A. Wood, M. M. Zaleska, E. I. Graziani, K. Pong. J. Neurosci. Meth. 163, 310 (2007). (http://dx.doi.org/10.1016/j.jneumeth.2007.03.018)
• 38. E. Graziani. In RSC Drug Discovery Series, #4. Accounts in Drug Discovery: Case Studies in Medicinal Chemistry, J. C. Barrish, P. H. Carter, P. T. W. Cheng, R. Zohler (Eds.), pp. 316–330, RCS Publishing, London (2011).
• 39. Neuronal survival was determined by measuring neurofilament content in cultured rat cortical neurons using an ELISA assay.
• 40. T. D. Ocain, K. Longhi, R. J. Steffan, R. G. Caccese, S. N. Sehgal. Biochem. Biophys. Res. Commun. 192, 1340 (1993). (http://dx.doi.org/10.1006/bbrc.1993.1563)
• 41. In vitro immunosuppression was measured as the inhibition of IL-2-stimulated human CD4+ T cell proliferation.
• 42. M. Abou-Gharbia. J. Med. Chem. 52, 2 (2009). (http://dx.doi.org/10.1021/jm8012823)
• 43. B. Ruan, K. Pong, F. Jow, M. Bowlby, R. A. Crozier, D. Liu, S. Liang, Y. Chen, M. L. Mercado, X. Feng, F. Bennett, D. von Schack, L. McDonald, M. M. Zaleska, A. Wood, P. H. Reinhart, R. L. Magolda, J. Skotnicki, M. N. Pangalos, F. E. Koehn, G. T. Carter, M. Abou-Gharbia, E. I. Graziani. Proc. Natl. Acad. Sci. USA 105, 33 (2008). (http://dx.doi.org/10.1073/pnas.0710424105)
• 44. J. Sharkey, S. P. Butcher. Nature 371, 336 (1994). (http://dx.doi.org/10.1038/371336a0)
• 45. Manuscript in preparation.
• 46. B. G. Gold, V. Densmore, W. Shou, M. M. Matzuk, H. S. Gordon. J. Pharmacol. Exp. Ther. 289, 1202 (1999).