CrossRef enabled

PAC Archives

Archive →

Pure Appl. Chem., 2012, Vol. 84, No. 6, pp. 1445-1453

Published online 2012-04-02

Synthesis of saxitoxins

Osamu Iwamoto, Takafumi Akimoto and Kazuo Nagasawa*

Department of Biotechnology and Life Science, Faculty of Technology, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan

Abstract: Saxitoxin (STX), a neurotoxin isolated from Alaskan butter clam, Saxidomus giganteus, inhibits voltage-gated sodium channels by binding to the pore-forming p-loop region. Here we describe stereospecific syntheses of STX and its natural derivatives, (+)‑decarbamoylsaxitoxin (dcSTX) and (+)-gonyautoxin3 (GTX3).