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Pure Appl. Chem., 2012, Vol. 84, No. 6, pp. 1353-1367

http://dx.doi.org/10.1351/PAC-CON-11-10-08

Published online 2012-04-15

Antiproliferative withanolides from the Solanaceae: A structure–activity study

Huaping Zhang1, Abbas K. Samadi2, Mark S. Cohen2 and Barbara N. Timmermann1*

1 Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA
2 Department of Surgery, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA

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  • Zhang Huaping, Hagan Kyra, Patel Ojas, Tong Xiaoqin, Day Victor W., Timmermann Barbara N.: 6α,7α-Epoxy-5α-hydroxy-1-oxo-22R-witha-2,24-dienolide(withanolide B), 5β,6β-Epoxy-4β,20-dihydroxy-1-oxo-22R-witha-2,24-dienolide(withanolide D), and 4β,27-Dihydroxy-1-oxo-22R-witha-2,5,24-trienolide(5,6-deoxywithaferin A) in Roots of Withania somnifera: Isolation and Their Crystal Structures. J Chem Crystallogr 2014, 44, 169. <http://dx.doi.org/10.1007/s10870-014-0499-1>
  • Zhang Huaping, Cao Cong-Mei, Gallagher Robert J., Day Victor W., Montenegro Gloria, Timmermann Barbara N.: Withanolides from Jaborosa caulescens var. bipinnatifida. Phytochemistry 2014, 98, 232. <http://dx.doi.org/10.1016/j.phytochem.2013.11.005>
  • Cao Cong-Mei, Zhang Huaping, Gallagher Robert J., Day Victor W., Kindscher Kelly, Grogan Patrick, Cohen Mark S., Timmermann Barbara N.: Withanolides from Physalis hispida. J. Nat. Prod. 2014, 140123161524003. <http://dx.doi.org/10.1021/np400953n>
  • Motiwala Hashim F., Bazzill Joseph, Samadi Abbas, Zhang Huaping, Timmermann Barbara N., Cohen Mark S., Aubé Jeffrey: Synthesis and Cytotoxicity of Semisynthetic Withalongolide A Analogues. ACS Med. Chem. Lett. 2013, 4, 1069. <http://dx.doi.org/10.1021/ml400267q>
  • Zhang Huaping, Bazzill Joseph, Gallagher Robert J., Subramanian Chitra, Grogan Patrick T., Day Victor W., Kindscher Kelly, Cohen Mark S., Timmermann Barbara N.: Antiproliferative Withanolides from Datura wrightii. J. Nat. Prod. 2013, 76, 445. <http://dx.doi.org/10.1021/np300766p>
  • Cao Cong-Mei, Zhang Huaping, Gallagher Robert J., Timmermann Barbara N.: Withanolide Artifacts Formed in Methanol. J. Nat. Prod. 2013, 76, 2040. <http://dx.doi.org/10.1021/np400296s>
  • El Bouzidi Laila, Mahiou-Leddet Valérie, Bun Sok-Siya, Larhsini Mustapha, Abbad Abdelaziz, Markouk Mohammed, Fathi Mabrouki, Boudon Michèle, Ollivier Evelyne, Bekkouche Khalid: Cytotoxic withanolides from the leaves of Moroccan Withania frutescens. Pharmaceutical Biology 2013, 51, 1040. <http://dx.doi.org/10.3109/13880209.2013.775162>
  • Kindscher Kelly, Long Quinn, Corbett Steve, Bosnak Kirsten, Loring Hillary, Cohen Mark, Timmermann Barbara N.: The Ethnobotany and Ethnopharmacology of Wild Tomatillos, Physalis longifolia Nutt., and Related Physalis Species: A Review. Econ Bot 2012, 66, 298. <http://dx.doi.org/10.1007/s12231-012-9210-7>