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Pure Appl. Chem., 2010, Vol. 82, No. 7, pp. 1503-1515

Published online 2010-05-30

Catalytic synthesis of amines and N-containing heterocycles: Amidate complexes for selective C–N and C–C bond-forming reactions

Patrick Eisenberger and Laurel L. Schafer*

Department of Chemistry, University of British Columbia, 6174 University Blvd., Vancouver, BC V6T 1Z1, Canada

Abstract: The direct, 100 % atom-economic, and selective synthesis of amines is a challenging task that can be achieved, making use of early transition-metal catalysts. Here we report the synthesis and application of group 4 and 5 high-oxidation-state metal amidate complexes in catalytic C–N (hydroamination) and C–C (hydroaminoalkylation) bond-forming reactions to access substituted amines.