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Pure Appl. Chem., 2010, Vol. 82, No. 3, pp. 577-582

Published online 2010-02-14

Asymmetric synthesis of aminophosphonic acids mediated by chiral sulfinyl auxiliary: Recent advances

Piotr Łyżwa and Marian Mikołajczyk*

Department of Heteroorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 90-363 Łódź, Sienkiewicza 112, Poland

Abstract: New approaches to asymmetric synthesis of α-, β- and γ-aminophosphonic acids using enantiopure p-toluenesulfinimines as key reagents are reported. The utility of the devised methods is illustrated by the syntheses of enantiomeric aminophosphonic acids such as AP4, AP3, and its 3-amino isomer.