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Pure Appl. Chem., 2008, Vol. 80, No. 8, pp. 1773-1782

Total synthesis of cytotoxic marine macrolides: Callipeltoside A, aurisides A and B, and dolastatin 19

Ian Paterson and Alison D. Findlay

University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK

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  • Grupe Sabine, Jacobi von Wangelin Axel: Iron-Catalyzed Synthesis of Cyclopropyl Halides. ChemCatChem 2013, 5, 706. <>
  • Aros D., Gonzalez V., Allemann R. K., Muller C. T., Rosati C., Rogers H. J.: Volatile emissions of scented Alstroemeria genotypes are dominated by terpenes, and a myrcene synthase gene is highly expressed in scented Alstroemeria flowers. J Exper Botany 2012, 63, 2739. <>
  • D’Orazio Nicolantonio, Gammone Maria Alessandra, Gemello Eugenio, De Girolamo Massimo, Cusenza Salvatore, Riccioni Graziano: Marine Bioactives: Pharmacological Properties and Potential Applications against Inflammatory Diseases. Marine Drugs 2012, 10, 812. <>
  • Pettit George R., Smith Thomas H., Xu Jun-Ping, Herald Delbert L., Flahive Erik J., Anderson Collin R., Belcher Paul E., Knight John C.: Antineoplastic Agents. 590. X-ray Crystal Structure of Dolastatin 16 and Syntheses of the Dolamethylleuine and Dolaphenvaline Units. J Nat Prod 2011, 74, 1003. <>
  • Bourcet Emmanuel, Fache Fabienne, Piva Olivier: Stereocontrolled Synthesis of the Highly Functionalized Core Structure of Aurisides by Ring-Closing Metathesis. Eur J Org Chem 2010, 2010, 4075. <>
  • Bourcet Emmanuel, Fache Fabienne, Piva Olivier: Synthesis of the macrolactone structure of the aurisides. Tetrahedron 2010, 66, 1319. <>
  • Morales-Serna José Antonio, Sánchez Ericka, Velázquez Ricardo, Bernal Jorge, García-Ríos Eréndira, Gaviño Rubén, Negrón-Silva Guillermo, Cárdenas Jorge: Highly efficient macrolactonization of ω-hydroxy acids using benzotriazole esters: synthesis of Sansalvamide A. Org Biomol Chem 2010, 8, 4940. <>
  • Paterson Ian, Findlay Alison D.: ChemInform Abstract: Total Synthesis of Cytotoxic Marine Macrolides: Callipeltoside A, Aurisides A and B, and Dolastatin 19. ChemInform 2009, 40. <>