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Pure Appl. Chem., 2008, Vol. 80, No. 8, pp. 1703-1718

Oxidation-responsiveness of nanomaterials for targeting inflammatory reactions

Vitaliy V. Khutoryanskiy1 and Nicola Tirelli2

1 School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6AD, UK
2 School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK

Abstract: Oxidation is an almost ubiquitous feature of inflammatory reactions. We discuss the development of nanocarriers that respond to the presence of oxidants with profound physical reorganization, which could in perspective allow their use for delivering anti-inflammatory principles in an inflammation-responsive fashion. We also present a study demonstrating that the response of polysulfide nanoparticles has a bulk character, i.e., the odixation reactions happen homogeneously throughout the nanoparticles, and not interfacially.