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Pure Appl. Chem., 2008, Vol. 80, No. 5, pp. 1161-1166

Palladium-catalyzed cross-addition of triisopropylsilylacetylene to unactivated alkynes

Naofumi Tsukada, Satoshi Ninomiya, Yoshimi Aoyama and Yoshio Inoue

Graduate School of Engineering, Tohoku University, Aoba, Sendai 980-8579, Japan

Abstract: Selective cross-addition of triisopropylsilylacetylene (TIPSA) to unactivated alkynes is catalyzed by dinuclear and mononuclear palladium complexes supported by a multidentate ligand, N,N'-bis[2-(diphenylphosphino)phenyl]formamidine (dpfamH). While the addition reactions of TIPSA to dialkylacetylenes using palladium catalysts supported by monodentate and bidentate ligands gives dimers of TIPSA as major products, the reactions with the palladium complexes supported by dpfam affords cross-adducts selectively, in which the yields of TIPSA dimers are less than 5 %. The addition of TIPSA to monoalkylacetylenes also gives cross-adducts as major products, although the selectivity and yield are moderate.