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Pure Appl. Chem., 2007, Vol. 79, No. 4, pp. 739-751

http://dx.doi.org/10.1351/pac200779040739

Diversity in isoprene unit biosynthesis: The methylerythritol phosphate pathway in bacteria and plastids

Michel Rohmer

Université Louis Pasteur/CNRS, Institut de Chemie, 4 rue Blaise Pascal, 67070 Strasbourg Cédex, France

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  • Gauss Dominik, Schoenenberger Bernhard, Wohlgemuth Roland: Chemical and enzymatic methodologies for the synthesis of enantiomerically pure glyceraldehyde 3-phosphates. Carbohydrate Research 2014. <http://dx.doi.org/10.1016/j.carres.2013.12.023>
  • Chang Wei-chen, Song Heng, Liu Hung-wen, Liu Pinghua: Current development in isoprenoid precursor biosynthesis and regulation. Current Opinion in Chemical Biology 2013, 17, 571. <http://dx.doi.org/10.1016/j.cbpa.2013.06.020>
  • Zhao Lishan, Chang Wei-chen, Xiao Youli, Liu Hung-wen, Liu Pinghua: Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis. Annu. Rev. Biochem. 2013, 82, 497. <http://dx.doi.org/10.1146/annurev-biochem-052010-100934>
  • Li Heng, Dai Shao-Bo, Gao Wen-Yun: Preparation of Isotope Labeled/Unlabeled Key Intermediates in 2-Methyl-D-erythritol 4-Phosphate Terpenoid Biosynthetic Pathway. J Helv Chim Acta 2012, 95, 683. <http://dx.doi.org/10.1002/hlca.201100396>
  • Zinglé Catherine, Kuntz Lionel, Tritsch Denis, Grosdemange-Billiard Catherine, Rohmer Michel: Modifications around the hydroxamic acid chelating group of fosmidomycin, an inhibitor of the metalloenzyme 1-deoxyxylulose 5-phosphate reductoisomerase (DXR). Bioorganic & Medicinal Chemistry Letters 2012, 22, 6563. <http://dx.doi.org/10.1016/j.bmcl.2012.09.021>
  • Ponaire Sarah, Zingl�� Catherine, Tritsch Denis, Grosdemange-Billiard Catherine, Rohmer Michel: Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agents. European Journal of Medicinal Chemistry 2012. <http://dx.doi.org/10.1016/j.ejmech.2012.02.031>
  • Span Ingrid, Gräwert Tobias, Bacher Adelbert, Eisenreich Wolfgang, Groll Michael: Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis. J Mol Bio 2012, 416, 1. <http://dx.doi.org/10.1016/j.jmb.2011.11.033>
  • Stadler Adrian-Mihail, Harrowfield Jack: Places and chemistry: Strasbourg—a chemical crucible seen through historical personalities. Chem Soc Rev 2011, 40, 2061. <http://dx.doi.org/10.1039/c0cs00197j>
  • Li Heng, Tian Jie, Wang Hui, Yang Shao-Qing, Gao Wen-Yun: An Improved Preparation of D-Glyceraldehyde 3-Phosphate and Its Use in the Synthesis of 1-Deoxy-D-xylulose 5-Phosphate. HCA 2010, 93, 1745. <http://dx.doi.org/10.1002/hlca.200900441>
  • Crick Dean C., Narayanasamy Prabagaran, Eoh Hyungjin, Brennan Patrick J.: Synthesis of 4-Diphosphocytidyl-2-C-Methyl-D-Erythritol 2-Phosphate and Kinetic Studies of Mycobacterium tuberculosis IspF. CHEM BIOL 2010, 17, 117. <http://dx.doi.org/10.1016/j.chembiol.2010.01.013>
  • Schramek Nicholas, Wang Huahong, Römisch-Margl Werner, Keil Birgit, Radykewicz Tanja, Winzenhörlein Bernhard, Beerhues Ludger, Bacher Adelbert, Rohdich Felix, Gershenzon Jonathan: Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. Phytochemisry 2010, 71, 179. <http://dx.doi.org/10.1016/j.phytochem.2009.10.015>
  • Rohmer Michel: From Molecular Fossils of Bacterial Hopanoids to the Formation of Isoprene Units: Discovery and Elucidation of the Methylerythritol Phosphate Pathway. Lipid 2008, 43, 1095. <http://dx.doi.org/10.1007/s11745-008-3261-7>