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Pure Appl. Chem., 2007, Vol. 79, No. 4, pp. 469-479

Development of huperzine A and B for treatment of Alzheimer's disease

Donglu Bai

Shanghai Institute of Materia Medica, Chinese Academy of Sciences,555 Zuchongzhi Road, Shanghai, 201203, China

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  • Drtinova Lucie, Dobes Petr, Pohanka Miroslav: Low molecular weight precursor applicable for Alzheimer disease drugs synthesis (AChE and BChE inhibition, BACE inhibition, antioxidant properties and in silico modulation). Journal of Applied Biomedicine 2014. <>
  • Ishiuchi Kan’ichiro, Park Jeong-Jin, Long Robert M., Gang David R.: Production of huperzine A and other Lycopodium alkaloids in Huperzia species grown under controlled conditions and in vitro. Phytochemistry 2013, 91, 208. <>
  • Ding Rui, Lu YunYu, Yao HeQuan, Sun BingFeng, Lin GuoQiang: A new approach to the bicyclo[3.3.1]nonane framework of huperzine A-like molecules via palladium-catalyzed intramolecular γ-arylation. Sci. China Chem. 2012, 55, 1097. <>
  • Ding Xiao-Hua, Li Xiang, Liu Dan, Cui Wei-Chen, Ju Xuan, Wang Shaozhong, Yao Zhu-Jun: Target-oriented multifunctional organocatalysis for enantioselective synthesis of bicyclo[3.3.1]nona-2,6-dien-9-ones. A formal asymmetric synthesis of huperzine A. Tetrahedron 2012, 68, 6240. <>
  • Lin Hong-Yu, Causey Robert, Garcia Gregory E., Snider Barry B.: Synthesis of (±)-7-Hydroxylycopodine. J. Org. Chem. 2012, 77, 7143. <>
  • Ding Rui, Sun Bing-Feng, Lin Guo-Qiang: An Efficient Total Synthesis of (−)-Huperzine A‡. Org. Lett. 2012, 14, 4446. <>
  • Mehta Mona, Adem Abdu, Sabbagh Marwan: New Acetylcholinesterase Inhibitors for Alzheimer's Disease. International Journal of Alzheimer's Disease 2012, 2012, 1. <>
  • Ha Giang T., Wong Ryan K., Zhang Yan: Huperzine A as Potential Treatment of Alzheimer's Disease: An Assessment on Chemistry, Pharmacology, and Clinical Studies. C&B 2011, 8, 1189. <>
  • Pohanka Miroslav: Cholinesterases, a target of pharmacology and toxicology. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2011, 155, 219. <>
  • Grondal Christoph, Jeanty Matthieu, Enders Dieter: Organocatalytic cascade reactions as a new tool in total synthesis. Nature Chem 2010, 2, 167. <>
  • Silvestri Romano: Boom in the development of non-peptidic β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease. Med Res Rev 2009, 29, 295. <>
  • Haigh Julian R., Johnston Scott R., Peppernay Adam, Mattern Patrick J., Garcia Gregory E., Doctor Bhupendra P., Gordon Richard K., Aisen Paul S.: Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: Next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase. Chemico Biological Interactions 2008, 175, 380. <>