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Pure Appl. Chem., 2007, Vol. 79, No. 12, pp. 2189-2216

http://dx.doi.org/10.1351/pac200779122189

Promising agents at the interface of biology and oncology derived through chemical synthesis*

Rebecca M. Wilson1 and Samuel J. Danishefsky1,2

1 Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA
2 Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, NY 10027, USA

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  • Dong Suwei, Shang Shiying, Tan Zhongping, Danishefsky Samuel J.: Toward Homogeneous Erythropoietin: Application of Metal-Free Dethiylation in the Chemical Synthesis of the Ala79-Arg166 Glycopeptide Domain. Isr J Chem 2011, 51, 968. <http://dx.doi.org/10.1002/ijch.201100077>
  • Wilson Rebecca M., Danishefsky Samuel J.: Zum Wirkungsbereich der chemischen Synthese: Aufbau einer Minipipeline in einem akademischen Labor. Angew Chem 2010, 122, 6168. <http://dx.doi.org/10.1002/ange.201000775>
  • Tan Zhongping, Shang Shiying, Danishefsky Samuel J.: Insights into the Finer Issues of Native Chemical Ligation: An Approach to Cascade Ligations. Angew. Chem. 2010, 122, 9690. <http://dx.doi.org/10.1002/ange.201005513>
  • Wilson Rebecca M., Danishefsky Samuel J.: On the Reach of Chemical Synthesis: Creation of a Mini-Pipeline from an Academic Laboratory. Angew Chem Int Ed 2010, 49, 6032. <http://dx.doi.org/10.1002/anie.201000775>
  • Tan Zhongping, Shang Shiying, Danishefsky Samuel J.: Insights into the Finer Issues of Native Chemical Ligation: An Approach to Cascade Ligations. Angew. Chem. Int. Ed. 2010, 49, 9500. <http://dx.doi.org/10.1002/anie.201005513>
  • Conroy Trent, Jolliffe Katrina A., Payne Richard J.: Synthesis of N-linked glycopeptides via solid-phase aspartylation. Org Biomol Chem 2010, 8, 3723. <http://dx.doi.org/10.1039/c003673k>
  • Kan Cindy, Danishefsky Samuel J.: Recent departures in the synthesis of peptides and glycopeptides. Tetrahedron 2009, 65, 9047. <http://dx.doi.org/10.1016/j.tet.2009.09.032>
  • Tan Zhongping, Shang Shiying, Halkina Tamara, Yuan Yu, Danishefsky Samuel J.: Toward Homogeneous Erythropoietin: Non-NCL-Based Chemical Synthesis of the Gln78−Arg166 Glycopeptide Domain. J Am Chem Soc 2009, 131, 5424. <http://dx.doi.org/10.1021/ja808704m>
  • Yuan Yu, Chen Jin, Wan Qian, Tan Zhongping, Chen Gong, Kan Cindy, Danishefsky Samuel J.: Toward Homogeneous Erythropoietin: Fine Tuning of the C-Terminal Acyl Donor in the Chemical Synthesis of the Cys29−Gly77 Glycopeptide Domain. J Am Chem Soc 2009, 131, 5432. <http://dx.doi.org/10.1021/ja808705v>
  • Kan Cindy, Trzupek John D., Wu Bin, Wan Qian, Chen Gong, Tan Zhongping, Yuan Yu, Danishefsky Samuel J.: Toward Homogeneous Erythropoietin: Chemical Synthesis of the Ala1−Gly28 Glycopeptide Domain by “Alanine” Ligation. J Am Chem Soc 2009, 131, 5438. <http://dx.doi.org/10.1021/ja808707w>
  • Zhu Jianglong, Wan Qian, Ragupathi Govind, George Constantine M., Livingston Philip O., Danishefsky Samuel J.: Biologics through Chemistry: Total Synthesis of a Proposed Dual-Acting Vaccine Targeting Ovarian Cancer by Orchestration of Oligosaccharide and Polypeptide Domains. J Am Chem Soc 2009, 131, 4151. <http://dx.doi.org/10.1021/ja810147j>
  • Chen Jin, Wan Qian, Yuan Yu, Zhu Jianglong, Danishefsky Samuel J.: Native Chemical Ligation at Valine: A Contribution to Peptide and Glycopeptide Synthesis. Angew Chem 2008, 120, 8649. <http://dx.doi.org/10.1002/ange.200803523>
  • Chen Jin, Wan Qian, Yuan Yu, Zhu Jianglong, Danishefsky Samuel J.: Native Chemical Ligation at Valine: A Contribution to Peptide and Glycopeptide Synthesis. Angew Chem Int Ed 2008, 47, 8521. <http://dx.doi.org/10.1002/anie.200803523>