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Pure Appl. Chem., 2006, Vol. 78, No. 2, pp. 351-361

Palladium-catalyzed ring-forming reactions: Methods and applications

Mark Lautens, Dino Alberico, Cyril Bressy, Yuan-Qing Fang, Brian Mariampillai and Thorsten Wilhelm

Davenport Laboratories, Chemistry Department, University of Toronto, Toronto, Ontario M5S 3H6, Canada

Abstract: Several Pd-catalyzed cyclization methods were developed, including norbornene-mediated Catellani-type reactions, a Pd-catalyzed coupling reaction of aryl iodides and allyl moieties, and a tandem C-N/C-C coupling of gem-dihalovinyl systems. These ring-forming methods were applied to the synthesis of highly functionalized carbocyclic and heterocyclic compounds. Intermolecular Pd-catalyzed methods for synthesis of highly substituted arene compounds were also developed.