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Pure Appl. Chem., 2005, Vol. 77, No. 9, pp. 1641-1654



Postgenomic chemistry (IUPAC Technical Report)

Sergey Varfolomeyev1*, Elena Efremenko1, Irina Beletskaya1, Ivano Bertini2, G. Michael Blackburn3, Alexey Bogdanov4, Raimond Cunin5, Jutta Eichler6, Igor Galaev7, Vadim Gladyshev8, David O'Hagan9, Thomas Haertle10, Jaak Jarv11, Arkadiy Karyakin1, Ilia Kurochkin1, Marian Mikołajczyk12, Vladimir Poroikov13, Ivan Sakharov1, Friedrich Spener14, Normand Voyer15 and James Wild16

1 Chemical Enzymology Department, The M. V. Lomonosov Moscow State University, Lenin's Hills, 1/11, Moscow 119992, Russia
2 Magnetic Resonance Center, University of Florence, Italy
3 University of Sheffield, UK
4 Belozersky Institute, Moscow State University, Russia
5 Vrije University, Belgium
6 German Research Center of Biotechnology, Germany
7 Lund Universitiet Brussel, Sweden
8 University of Nebraska, USA
9 University of St. Andrews, UK
10 Institute of National Research Agronomy, France
11 University of Tartu, Estonia
12 Center of Molecular and Macromolecular Studies, Polish Academy of Sciences, Poland
13 Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Russia
14 University of Münster, Germany
15 Laval University, Canada
16 Texas A&M University, USA

Abstract: Numerous areas of chemistry can benefit from the ongoing genomic revolution. Here, we discuss and highlight trends in chemistry in the postgenomic era. The areas of interest include combinatorial approaches in organic chemistry; design and analysis of proteins containing unnatural amino acids; trace element-containing proteins; design and characterization of new enzyme types; applications of postgenomic chemistry in drug design; identification of lipid networks and global characterization of lipid molecular species; development of recombinant and self-proliferating polymers; and applications in food chemistry and bioanalytical chemistry based on new nanoanalytical systems and novel recognition elements.