CrossRef enabled

PAC Archives

Archive →

Pure Appl. Chem., 2005, Vol. 77, No. 1, pp. 179-184

Novel pyrrole-containing hypoglycemic and hypotriglyceridemic compounds

Braj B. Lohray* and Vidya Lohray

Zydus Research Center, Moraiya, Ahmedabad 382 210, India

Abstract: Several substituted α-alkoxy phenyl propionic acids were synthesized, and their hypotriglyceridemic properties were evaluated in Swiss albino mice. Some of the compounds showed excellent triglyceride- and cholesterol-lowering properties even at a dose of 1 mg/kg. 2,5-Substituted pyrrole-containing heterocycles were among the most potent alkoxy propionic acid class of compounds. These compounds also showed excellent antidiabetic activities in animal models.