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Pure Appl. Chem., 2003, Vol. 75, No. 2-3, pp. 407-412

Natural and totally synthetic receptors in the innovative design of HPLC chiral stationary phases

Francesco Gasparrini, Ilaria D'Acquarica, D. Misiti, M. Pierini and C. Villani

Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente

Attive, Università “La Sapienza”, P. le A. Moro 5, 00185 Roma, Italy

Abstract: An overview is presented of the experimental results obtained by our group in the design, realization, and applications of high-performance liquid chromatography (HPLC) enantioselective stationary phases based on surface-linked macrocyclic receptors. Macrocyclic synthetic receptors and macrocyclic glycopeptide receptors have been grafted on silica particles, and the resulting chiral stationary phases are used to monitor differential associations of the enantiomers of selected chiral guests with the immobilized hosts. Practical implications of the chiral phases in enantioselective analysis and in the study of recognition events are highlighted.