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Pure Appl. Chem., 2001, Vol. 73, No. 9, pp. 1465-1475

http://dx.doi.org/10.1351/pac200173091465

Gradient HPLC in the determination of drug lipophilicity and acidity

Roman Kaliszan, Piotr Haber, Tomasz Baczek and Danuta Siluk

Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Gen. J. Hallera 107, 80-416 Gdansk, Poland

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  • Socia Adam, Foley Joe P.: Sequential elution liquid chromatography can significantly increase the probability of a successful separation by simultaneously increasing the peak capacity and reducing the separation disorder. Journal of Chromatography A 2014, 1324, 36. <http://dx.doi.org/10.1016/j.chroma.2013.11.016>
  • Wiczling P., Struck-Lewicka W., Kubik Ł., Siluk D., Markuszewski M.J., Kaliszan R.: The simultaneous determination of hydrophobicity and dissociation constant by liquid chromatography–mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2014, 94, 180. <http://dx.doi.org/10.1016/j.jpba.2014.01.038>
  • Komsta Ł., Gowin E.: Revisiting thin-layer chromatography as a lipophilicity determination tool. Part IV — A closer look on extrapolation and averaging. Acta Chromatographica 2014, 26, 1. <http://dx.doi.org/10.1556/AChrom.26.2014.1.1>
  • Yüksek Haydar, Akyıldırım Onur, Yola Mehmet L., Gürsoy-Kol Özlem, Çelebier Mustafa, Kart Didem: Synthesis, In Vitro Antimicrobial and Antioxidant Activities of Some New 4,5-Dihydro-1 H -1,2,4-triazol-5-one Derivatives. Arch. Pharm. Pharm. Med. Chem. 2013, 346, 470. <http://dx.doi.org/10.1002/ardp.201300048>
  • Vastag Gyöngyi, Apostolov Suzana, Perišić-Janjić Nada, Matijević Borko: Multivariate analysis of chromatographic retention data and lipophilicity of phenylacetamide derivatives. Analytica Chimica Acta 2013, 767, 44. <http://dx.doi.org/10.1016/j.aca.2013.01.002>
  • Vastag Gyöngyi, Apostolov Suzana, Nakomčić Jelena, Matijević Borko: APPLICATION OF CHEMOMETRIC METHODS IN EXAMINING OF THE RETENTION BEAHAVIOR AND LIPOPHILICITY OF NEWLY SYNTHESIZED CYANOACETAMIDE DERIVATIVES. Journal of Liquid Chromatography & Related Technologies 2013, 131121093418006. <http://dx.doi.org/10.1080/10826076.2013.850723>
  • Wiczling Paweł, Nasal Antoni, Kubik Łukasz, Kaliszan Roman: A new pH/organic modifier gradient RP HPLC method for convenient determination of lipophilicity and acidity of drugs as applied to established imidazoline agents. European Journal of Pharmaceutical Sciences 2012, 47, 1. <http://dx.doi.org/10.1016/j.ejps.2012.04.021>
  • Chen Yongjing, Srinivasan Kannan, Dasgupta Purnendu K.: Electrodialytic Membrane Suppressors for Ion Chromatography Make Programmable Buffer Generators. Anal Chem A 2012, 84, 67. <http://dx.doi.org/10.1021/ac2023712>
  • Kaliszan Roman, Wiczling Paweł: Gradient reversed-phase high-performance chromatography of ionogenic analytes. TrAC ? Trends Anal Chem 2011, 30, 1372. <http://dx.doi.org/10.1016/j.trac.2011.05.006>
  • Kawczak Piotr, Vander Heyden Yvan, Nasal Antoni, Bączek Tomasz, Drabczyñska Anna, Kieć-Kononowicz Katarzyna, Kaliszan Roman: Micellar liquid chromatography for lipophilicity determination of new biologically active 1,3-purinodiones. J Sep Science 2010, 33, 1546. <http://dx.doi.org/10.1002/jssc.200900752>
  • Henchoz Yveline, Bard Bruno, Guillarme Davy, Carrupt Pierre-Alain, Veuthey Jean-Luc, Martel Sophie: Analytical tools for the physicochemical profiling of drug candidates to predict absorption/distribution. Anal Bioanal Chem 2009, 394, 707. <http://dx.doi.org/10.1007/s00216-009-2634-y>
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  • Odovic Jadranka, Trbojevic-Stankovic Jasna: Chromatography methods in investigation of lipophilicity of the biological active substances. Hem Ind 2009, 63, 33. <http://dx.doi.org/10.2298/HEMIND0901033O>
  • Bajda Marek, Boryczka Stanisław, Wietrzyk Joanna, Malawska Barbara: Investigation of lipophilicity of anticancer-active thioquinoline derivatives. Biomed Chromatogr 2007, 21, 123. <http://dx.doi.org/10.1002/bmc.706>
  • DUREJA HARISH, KUMAR VIPIN, GUPTA SUNIL, MADAN ANIL KUMAR: TOPOCHEMICAL MODELS FOR THE PREDICTION OF LIPOPHILICITY OF 1,3-DISUBSTITUTED PROPAN-2-ONE ANALOGS. J. Theor. Comput. Chem. 2007, 06, 435. <http://dx.doi.org/10.1142/S021963360700309X>
  • Kaliszan Roman, Wiczling Pawel: Theoretical opportunities and actual limitations of pH gradient HPLC. Anal Bioanal Chem 2005, 382, 718. <http://dx.doi.org/10.1007/s00216-004-3023-1>
  • Wiczling Paweł, Markuszewski Michał J., Kaliszan Michał, Galer Katarzyna, Kaliszan Roman: Combined pH/organic solvent gradient HPLC in analysis of forensic material. J  Pharm Biomed Anal 2005, 37, 871. <http://dx.doi.org/10.1016/j.jpba.2004.06.031>
  • Vonk Erik C., Lewandowska Katarzyna, Claessens Henk A., Kaliszan Roman, Cramers Carel A.: Quantitative structure-retention relationships in reversed-phase liquid chromatography using several stationary and mobile phases. J Sep Science 2003, 26, 777. <http://dx.doi.org/10.1002/jssc.200301328>
  • Kaliszan Roman, B??czek Tomasz, Buciński Adam, Buszewski Bogusław, Sztupecka Małgorzata: Prediction of gradient retention from the linear solvent strength (LSS) model, quantitative structure-retention relationships (QSRR), and artificial neural networks (ANN). J Sep Science 2003, 26, 271. <http://dx.doi.org/10.1002/jssc.200390033>
  • Beltrán J.L., Sanli N., Fonrodona G., Barrón D., Özkan G., Barbosa J.: Spectrophotometric, potentiometric and chromatographic pKa values of polyphenolic acids in water and acetonitrile–water media. Analytica Chimica Acta 2003, 484, 253. <http://dx.doi.org/10.1016/S0003-2670(03)00334-9>