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Pure Appl. Chem., 2001, Vol. 73, No. 8, pp. 1299-1303

Low-temperature manufacturing of fine pharmaceutical powders with supercritical fluid aerosolization in a Bubble Dryer®

R. E. Sievers1*, E. T. S. Huang1, J. A. Villa1, J. K. Kawamoto1, M. M. Evans1 and P. R. Brauer2

1 Department of Chemistry and Biochemistry, 215 UCB, University of Colorado, Boulder, CO 80309-0215, USA
2 Temco, Inc., 4616 Mingo Rd., Tulsa, OK 74117, USA

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  • Rodríguez-Meizoso Irene, Castro-Puyana María, Börjesson Pål, Mendiola Jose A., Turner Charlotta, Ibáñez Elena: Life cycle assessment of green pilot-scale extraction processes to obtain potent antioxidants from rosemary leaves. The Journal of Supercritical Fluids 2012, 72, 205. <>
  • Manion J'aime R., Cape Stephen P., McAdams David H., Rebits Lia G., Evans Sarah, Sievers Robert E.: Inhalable Antibiotics Manufactured Through Use of Near-Critical or Supercritical Fluids. Aerosol Sci and Technol 2012, 46, 403. <>
  • Zalepugin D. Yu., Tilkunova N. A., Fronchek E. V., Gallyamov M. O., Chernyshova I. V., Mishin V. S., Yashin Yu. S., Grigoryev T. E., Gamzazade A. I., Khokhlov A. R.: Production of new haemostatic materials by deposition of dispersed proteins onto porous matrices using supercritical carbon dioxide. Russ J Phys Chem B 2010, 4, 1047. <>
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  • Vehring Reinhard: Pharmaceutical Particle Engineering via Spray Drying. Pharmaceutical Research (Dordrecht) 2008, 25, 999. <>
  • Cape Stephen P., Villa Joseph A., Huang Edward T. S., Yang Tzung-Horng, Carpenter John F., Sievers Robert E.: Preparation of Active Proteins, Vaccines and Pharmaceuticals as Fine Powders using Supercritical or Near-Critical Fluids. Pharmaceutical Research (Dordrecht) 2008, 25, 1967. <>
  • Okamoto Hirokazu, Danjo Kazumi: Application of supercritical fluid to preparation of powders of high-molecular weight drugs for inhalation. Adv Drug Delivery Rev 2008, 60, 433. <>
  • Rebits L.G., McAdams D.H., Burger J.L., Best J.A., Bhagwat P., Sievers R.E., Quinn B.P., Cape S.P., Searles J.A., Braun C.S.: Near-critical fluid micronization of stabilized vaccines, antibiotics and anti-virals. J Sup Fluids 2007, 42, 385. <>
  • Shoyele Sunday A., Cawthorne Simon: Particle engineering techniques for inhaled biopharmaceuticals. Adv Drug Delivery Rev 2006, 58, 1009. <>
  • Shariati Alireza, Peters Cor J.: Recent developments in particle design using supercritical fluids. Curr Opin Solid State Mater 2003, 7, 371. <>
  • Sievers R.E., Huang E.T.S., Villa J.A., Engling G., Brauer P.R.: Micronization of water-soluble or alcohol-soluble pharmaceuticals and model compounds with a low-temperature Bubble Dryer®. J Supercrit Fluids 2003, 26, 9. <>