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Pure Appl. Chem., 2001, Vol. 73, No. 7, pp. 1137-1145

Crystalline inclusion complexes as media of molecular recognitions and selective reactions

Fumio Toda

Department of Chemistry, Faculty of Science, Okayama University of Science, Ridai-cho 1-1, Okayama, 700-0005, Japan

Abstract: Hexaol host compounds which include guest molecules maximum in 1:6 ratio were prepared. Aromatic hexaol host, hexahydroxytriphenylene, was found to form chiral inclusion crystal by complexation with achiral guest molecules. Some interesting and important optical resolutions of rac-guests by inclusion complexation with a chiral host were described. When chemical reaction and the inclusion complexation procedures in a water suspension medium are combined, new economical and ecological method of the preparation of optically active compound can be established. When photochemical reactions are carried out in an inclusion crystal with a chiral host, enantioselective reactions occur, and optically active product can be obtained. Several successful reactions are described.