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Pure Appl. Chem., 2001, Vol. 73, No. 3, pp. 475-480

Vital role of entropy in photochirogenesis

Yoshihisa Inoue1*, Norimitsu Sugahara and Takehiko Wada

1 Inoue Photochirogenesis Project, ERATO, JST, 4-6-3 Kamishinden, Toyonaka 565-0085, Japan

Abstract: The effects of temperature, pressure, solvent, and substrate concentration upon several enantio- and diastereodifferentiating photochemical reactions have been investigated and discussed in detail. These entropy-related external factors, which manipulate the weak electronic and steric interactions in the excited state, dynamically control the stereochemical outcome of asymmetric photochemical reactions, and even switch the product chirality. A global view on the "entropy chemistry" and its potential applications are also discussed.