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Pure Appl. Chem., 2000, Vol. 72, No. 9, pp. 1705-1708

New nucleoside analogs, synthesis, and biological properties

M. J. Wanner, P. Y. F. Deghati, B. Rodenko and G. J. Koomen

Laboratory of Bioorganic Chemistry, IMC, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands

Abstract: In view of the importance of nucleoside analogs as enzyme inhibitors and adenosine receptor (ant)agonists, new adenosine analogs were prepared and their activities studied on adenosine deaminase in vitro and on A1, A2A, and A3 receptors. Particularly useful for the synthesis of new analogs were the applications of the Pd-catalyzed Buchwald reaction and a radical nitration reaction of purine- and 1-deazapurine nucleosides.