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Pure Appl. Chem., 1993, Vol. 65, No. 6, pp. 1189-1204

Reflections on the total synthesis of natural products: Art, craft, logic, and the chiron approach

S. Hanessian

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  • Görner Christian, Häuslein Ina, Schrepfer Patrick, Eisenreich Wolfgang, Brück Thomas: Targeted Engineering of Cyclooctat-9-en-7-ol Synthase: A Stereospecific Access to Two New Non-natural Fusicoccane-Type Diterpenes. ChemCatChem 2013, 5, 3289. <>
  • Magdycz Marta, Jarosz Sławomir: Synthesis of polyhydroxylated carbo-bicyclic compounds from sugar allyltins. Tetrahedron: Asymmetry 2013, 24, 1402. <>
  • Hanessian Stephen: The Enterprise of Synthesis: From Concept to Practice. J. Org. Chem. 2012, 77, 6657. <>
  • Hughes Amanda J., Detelich Joshua F., Keatinge-Clay Adrian T.: Employing a polyketide synthase module and thioesterase in the semipreparative biocatalysis of diverse triketide pyrones. Med. Chem. Commun. 2012, 3, 956. <>
  • Zhang HongKui, Li Xin, Huang Huang, Huang PeiQiang: Asymmetric syntheses of (8R,8aS)- and (8R,8aR)-8-hydroxy-5-indolizidinones: Two promising oxygenated indolizidine building blocks. Sci China Chem 2011, 54, 737. <>
  • Yang Chao, Bao Yu-Hui, Liang Pan, Ye Jian-Liang, Wang Ai-E., Huang Pei-Qiang: A new approach to the C28 fatty acid chain of the marine natural products schulzeines B and C: a concise diastereoselective total synthesis of(−)-schulzeine B. Tetrahedron 2011, 67, 6281. <>
  • Reddy Chada Raji, Latha Bellamkonda: Synthesis of (−)-dihydropinidine, (2S,6R)-isosolenopsin and (+)-monomorine via a chiral synthon from l-aspartic acid. Tet Asymm 2011, 22, 1849. <>
  • Wang Jun, Liu Xiaohua, Feng Xiaoming: Asymmetric Strecker Reactions. Chemistry Review 2011, 111, 6947. <>
  • Chau Jaclyn, Ciufolini Marco A.: The Chemical Synthesis of Tetrodoxin: An Ongoing Quest. Marine Drugs 2011, 9, 2046. <>
  • Tang Lijun, Wei Gongfan, Nandhakumar Raju, Guo Zhilong: Facile Synthesis of the Uryl Pendant Binaphthol Aldehyde and Its Selective Fluorescent Recognition of Tryptophan. Bull Kor Chem Soc 2011, 32, 3367. <>
  • HANESSIAN S.: ChemInform Abstract: Reflections on the Total Synthesis of Natural Products: Art, Craft, Logic, and the Chiron Approach. ChemInform 2010, 24, no. <>
  • Späth Andreas, Koch Carina, König Burkhard: Luminescent Hybrids Combining a Metal Complex and a Crown Ether - Receptors for Peptidic Ammonium Phosphates. Eur J Inorg Chem 2010, 2010, 2926. <>
  • Sun Chung-Ming, K. Gurjar Mukund, S. Yellol Gorakh, K. Mohapatra Debendra: Simple and Efficient One Pot Synthetic Protocol to Construct Morpholin-2-ones. HETEROCYCLES 2010, 82, 431. <>
  • Liao Lian-an, Zhang Fan, Yan Ni, Golen James A., Fox Joseph M.: An efficient and general method for resolving cyclopropene carboxylic acids. Tetrahedron 2004, 60, 1803. <>
  • Trost B. M.: Asymmetric Catalysis Special Feature Part I: Asymmetric catalysis: An enabling science. Proceedings of the National Academy of Sciences 2004, 101, 5348. <>
  • Fuchs P.L.: Increase in intricacy—a tool for evaluating organic syntheses. Tetrahedron 2001, 57, 6855. <>
  • Yang Hong Woon, Romo Daniel: Methods for the synthesis of optically active β-lactones (2-oxetanones). Tetrahedron 1999, 55, 6403. <>
  • Mehta Goverdhan, Barone René, Chanon Michel: Computer-Aided Organic Synthesis – SESAM: A Simple Program to Unravel “Hidden” Restructured Starting Materials Skeleta in Complex Targets. Eur J Org Chem 1998, 1998, 1409. <<1409::AID-EJOC1409>3.0.CO;2-H>
  • Takahata Hiroki, Uchida Yasuhiro, Momose Takefumi: New entry to chiral butenolide synthons. Application to expeditious syntheses of (+)-nephrosteranic acid, (+)-trans-whisky lactone, and (+)-trans-cognac lactone. Tetrahetron Lett 1994, 35, 4123. <>