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Pure Appl. Chem., 1990, Vol. 62, No. 2, pp. 289-294

http://dx.doi.org/10.1351/pac199062020289

The quest for a predictive design of anticancer drugs

G. Sosnovsky

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  • Chen Lu, Zhao Wei, Li Hong-Mei, Wang Duan-Ji, Li Dong-Sheng, Chen Tao, Yuan Zhan-Peng, Tang Ya-Jie: A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4′-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation. Bioorganic & Medicinal Chemistry 2014. <http://dx.doi.org/10.1016/j.bmc.2014.03.048>
  • Li Xiao-Jing, Yang Liu, Liu Ying-Qian, Li Chong: Synthesis of novel spin-labelled combretastatin A-4 derivatives as potential antineoplastic agents. Natural Product Research 2012, 26, 1271. <http://dx.doi.org/10.1080/14786419.2011.566222>
  • Chen Shi-Wu, Gao Yuan-Yu, Zhou Ni-Ni, Liu Jie, Huang Wen-Ting, Hui Ling, Jin Yan, Jin Yong-Xin: Carbamates of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis, cytotoxicity and cell cycle effects. Bioog Med Chem Lett 2011, 21, 7355. <http://dx.doi.org/10.1016/j.bmcl.2011.10.024>
  • Zhang Jia-Qiang, Zhang Zhi-Wei, Hui Ling, Chen Shi-Wu, Tian Xuan: Novel semisynthetic spin-labeled derivatives of podophyllotoxin with cytotoxic and antioxidative activity. Biorg Med Chem Lett 2010, 20, 983. <http://dx.doi.org/10.1016/j.bmcl.2009.12.048>
  • Chen Shi-Wu, Xiang Rong, Liu Jian, Tian Xuan: Synthesis and biological evaluation of novel conjugates of podophyllotoxin and 5-FU as antineoplastic agents. biorg med chem 2009, 17, 3111. <http://dx.doi.org/10.1016/j.bmc.2009.03.009>
  • Liu Ying-Qian, Tian Xuan, Yang Liu, Zhan Zong-Cheng: First synthesis of novel spin-labeled derivatives of camptothecin as potential antineoplastic agents. Eur J Med Chem 2008, 43, 2610. <http://dx.doi.org/10.1016/j.ejmech.2008.01.008>
  • Jin Yan, Chen Shi-Wu, Tian Xuan: Synthesis and biological evaluation of new spin-labeled derivatives of podophyllotoxin. biorg med chem 2006, 14, 3062. <http://dx.doi.org/10.1016/j.bmc.2005.12.025>
  • Liu Ying‐Qian, Tian Xuan: Synthesis of Novel Spin‐Labeled Derivatives of Podophyllotoxin as Potential Antineoplastic Agents. Synth Common 2005, 35, 2749. <http://dx.doi.org/10.1080/00397910500287983>
  • Wu Jian, Shi Weimin, Wu Di: Synthesis and Photocytotoxicity of Nitroxyl Radical-substituted Porphyrin. Chem Lett 2004, 33, 460. <http://dx.doi.org/10.1246/cl.2004.460>
  • Tian Xuan, Zhang Fu-min, Li Wen-guang: Antitumor and antioxidant activity of spin labeled derivatives of podophyllotoxin (GP-1) and congeners. Life Sci Oxford 2002, 70, 2433. <http://dx.doi.org/10.1016/S0024-3205(02)01482-0>
  • Gadjeva Vesselina G.: Two spin labeled triazenes: relationship between biochemical and biological activities. Int J of Pharmaceutics 2002, 247, 39. <http://dx.doi.org/10.1016/S0378-5173(02)00360-5>
  • Abdaoui Mohamed, Dewynter Georges, Toupet Loic, Montero Jean-Louis: Synthèse et Structure de 2-chloroéthylnitrososulfamides (CENS) dérivés d'Aminoacides. Partie 5. Tetrahedron 2000, 56, 2427. <http://dx.doi.org/10.1016/S0040-4020(00)00114-9>
  • Xu Shao-Jun, Ma Cheng, Wang Yan-Guang, Chen Yao-Zu: Synthesis of Novel Spin Labeled Analogues of N-(Trifluoroacetyl)Daunorubicin. Synth Common 2000, 30, 2375. <http://dx.doi.org/10.1080/00397910008086879>
  • Sosnovsky George, Bell Peter: In the search for new anticancer drugs. 29. A study on the correlation of lipophilicities, ionization constants and anticancer activities of aminoxyl labeled tepa congeners. Life Sci Oxford 1998, 62, 639. <http://dx.doi.org/10.1016/S0024-3205(97)01159-4>
  • Naik Neeta, Braslau Rebecca: Synthesis and applications of optically active nitroxides. Tetrahedron 1998, 54, 667. <http://dx.doi.org/10.1016/S0040-4020(97)10061-8>
  • Tian Xuan, Wang Yan-gwang, Yang Ming-gui, Chen Yao-zu: Synthesis and antitumor activity of spin labeled derivatives of podophyllotoxin. Life Sci Oxford 1997, 60, 511. <http://dx.doi.org/10.1016/S0024-3205(96)00689-3>
  • Wang Yan-guang, Pan Jian-lin, Shi Jian-feng, Chen* Yao-zu: NEW SPIN LABELED ANALOGUES OF PODOPHYLLOTOXIN AS POTENTIAL ANTITUMOR AGENTS. Life Sci Oxford 1997, 61, 537. <http://dx.doi.org/10.1016/S0024-3205(97)00413-X>
  • Lu Kuan-ke, Wang Yan-guang, Chen Yao-zu: Synthesis of Novel Spin Labeled Analogues of Podophyllotoxin Glycoside. Synth Common 1997, 27, 1963. <http://dx.doi.org/10.1080/00397919708006798>
  • Dewynter Georges, Abdaoui Mohamed, Regainia Zine, Montero Jean-Louis: Synthesis of n-sulfamoyloxazolidinones and -perhydrooxazinones reactivity and use as donors in the transsulfamoylation reaction; application to the preparation of 2-chloroethylnitrososulfamides. IV. Tetrahedron 1996, 52, 14217. <http://dx.doi.org/10.1016/0040-4020(96)00860-5>
  • Abdaoui Mohamed, Dewynter Georges, Aouf Nourredine, Favre Gilles, Morère Alain, Montero Jean-Louis: A new family of potential oncostatics: 2-chloroethylnitrososulfamides (CENS)—I. Synthesis, structure, and pharmacological evaluation (preliminary results). biorg med chem 1996, 4, 1227. <http://dx.doi.org/10.1016/0968-0896(96)00118-6>
  • Abdaoui Mohamed, Dewynter Georges, Aouf Noureddine, Montero Jean-Louis: SYNTHESIS OF 2-CHLOROETHYLNITROSOSULFAMIDES (CENS) VIA A TRANSSULFAMOYLATION REACTION. Phosphorus Sulfur Silicon Relat Elem 1996, 118, 39. <http://dx.doi.org/10.1080/10426509608038798>
  • Sosnovsky George, Lukszo Jan, Konieczny Maria, Purgstaller Klaus, Laib Frank: In the search for new anticancer drugs. 26. A comparison of anticancer activities of several tepa, thio-tepa, seleno-tepa, and azetidine analogs, including congeners containing an aminoxyl moiety. J Pharm Sci 1994, 83, 982. <http://dx.doi.org/10.1002/jps.2600830713>
  • Sosnovsky George, Gnewuch C. Thomas: In the search for new anticancer drugs. 27. Synthesis and comparison of anticancer activity in vivo of amino acids, carbohydrates, and carbohydrate-amino acid conjugates containing the [N′-(2-chloroethyl)-N′-nitrosoamino]carbonyl group. J Pharm Sci 1994, 83, 989. <http://dx.doi.org/10.1002/jps.2600830714>
  • Sosnovsky George, Baysal Mustafa, Erciyas Ercin: In the search for new anticancer drugs. 28. Synthesis and evaluation of highly active aminoxyl labeled amino acid derivatives containing the [N;-(2-chloroethyl)-N′-nitrosoamino]carbonyl group. J Pharm Sci 1994, 83, 999. <http://dx.doi.org/10.1002/jps.2600830715>
  • Subczynski Witold K., Wojas Jerzy, Wojas Jerzy, Wojas Jerzy, Pezeshk Vida, Pezeshk Abbas: Effects of probucol on phase transition and fluidity of phosphatidylcholine membranes: A spin label study. J  Inorg Biochem 1994, 55, 1. <http://dx.doi.org/10.1016/0162-0134(94)85127-1>
  • Sosnovsky George, Prakash Indra, Rao Nuti Uma Maheswara: In the search for new anticancer drugs. XXIV: Synthesis and anticancer activity of amino acids and dipeptides containing the 2-chloroethyl- and [N′-(2-chloroethyl)-N′-nitroso]-aminocarbonyl groups. J Pharm Sci 1993, 82, 1. <http://dx.doi.org/10.1002/jps.2600820102>
  • Pezeshk Abbas, Pezeshk Vida, Firlej Alina, Wojas Jerzy, Subczynski Witold K.: Transport of spin-labeled tetracycline across model and biological membranes. Life Sci Oxford 1993, 52, 1071. <http://dx.doi.org/10.1016/0024-3205(93)90200-M>
  • Pezeshk Abbas, Pezeshk Vida: Spectroscopic and biological studies of spin-labeled tetracycline. Life Sci Oxford 1992, 50, 1561. <http://dx.doi.org/10.1016/0024-3205(92)90147-H>
  • Pezeshk Abbas, Pezeshk Vida, Wojas Jerzy, Subczynski Witold K., Subczynski Witold K.: Partitional and motional properties of a spin-labeled daunomycin in lipid bilayers. An ESR study. J  Inorg Biochem 1992, 46, 67. <http://dx.doi.org/10.1016/0162-0134(92)80010-S>
  • Sosnovsky George, Rao Nuti Uma Maheshwara: In the search for new anticancer drugs. XXIII: Exploration of a predictive design for anticancer drugs of carbohydrates containingN-nitrosochloroethylamino,n-nitrosomethyl, andN-nitrosoaminoxyl components. J Pharm Sci 1991, 80, 693. <http://dx.doi.org/10.1002/jps.2600800717>