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Pure Appl. Chem., 1990, Vol. 62, No. 2, pp. 289-294

The quest for a predictive design of anticancer drugs

G. Sosnovsky

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  • Chen Lu, Zhao Wei, Li Hong-Mei, Wang Duan-Ji, Li Dong-Sheng, Chen Tao, Yuan Zhan-Peng, Tang Ya-Jie: A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4′-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation. Bioorganic & Medicinal Chemistry 2014. <>
  • Li Xiao-Jing, Yang Liu, Liu Ying-Qian, Li Chong: Synthesis of novel spin-labelled combretastatin A-4 derivatives as potential antineoplastic agents. Natural Product Research 2012, 26, 1271. <>
  • Chen Shi-Wu, Gao Yuan-Yu, Zhou Ni-Ni, Liu Jie, Huang Wen-Ting, Hui Ling, Jin Yan, Jin Yong-Xin: Carbamates of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis, cytotoxicity and cell cycle effects. Bioog Med Chem Lett 2011, 21, 7355. <>
  • Zhang Jia-Qiang, Zhang Zhi-Wei, Hui Ling, Chen Shi-Wu, Tian Xuan: Novel semisynthetic spin-labeled derivatives of podophyllotoxin with cytotoxic and antioxidative activity. Biorg Med Chem Lett 2010, 20, 983. <>
  • Chen Shi-Wu, Xiang Rong, Liu Jian, Tian Xuan: Synthesis and biological evaluation of novel conjugates of podophyllotoxin and 5-FU as antineoplastic agents. biorg med chem 2009, 17, 3111. <>
  • Liu Ying-Qian, Tian Xuan, Yang Liu, Zhan Zong-Cheng: First synthesis of novel spin-labeled derivatives of camptothecin as potential antineoplastic agents. Eur J Med Chem 2008, 43, 2610. <>
  • Jin Yan, Chen Shi-Wu, Tian Xuan: Synthesis and biological evaluation of new spin-labeled derivatives of podophyllotoxin. biorg med chem 2006, 14, 3062. <>
  • Liu Ying‐Qian, Tian Xuan: Synthesis of Novel Spin‐Labeled Derivatives of Podophyllotoxin as Potential Antineoplastic Agents. Synth Common 2005, 35, 2749. <>
  • Wu Jian, Shi Weimin, Wu Di: Synthesis and Photocytotoxicity of Nitroxyl Radical-substituted Porphyrin. Chem Lett 2004, 33, 460. <>
  • Tian Xuan, Zhang Fu-min, Li Wen-guang: Antitumor and antioxidant activity of spin labeled derivatives of podophyllotoxin (GP-1) and congeners. Life Sci Oxford 2002, 70, 2433. <>
  • Gadjeva Vesselina G.: Two spin labeled triazenes: relationship between biochemical and biological activities. Int J of Pharmaceutics 2002, 247, 39. <>
  • Abdaoui Mohamed, Dewynter Georges, Toupet Loic, Montero Jean-Louis: Synthèse et Structure de 2-chloroéthylnitrososulfamides (CENS) dérivés d'Aminoacides. Partie 5. Tetrahedron 2000, 56, 2427. <>
  • Xu Shao-Jun, Ma Cheng, Wang Yan-Guang, Chen Yao-Zu: Synthesis of Novel Spin Labeled Analogues of N-(Trifluoroacetyl)Daunorubicin. Synth Common 2000, 30, 2375. <>
  • Sosnovsky George, Bell Peter: In the search for new anticancer drugs. 29. A study on the correlation of lipophilicities, ionization constants and anticancer activities of aminoxyl labeled tepa congeners. Life Sci Oxford 1998, 62, 639. <>
  • Naik Neeta, Braslau Rebecca: Synthesis and applications of optically active nitroxides. Tetrahedron 1998, 54, 667. <>
  • Tian Xuan, Wang Yan-gwang, Yang Ming-gui, Chen Yao-zu: Synthesis and antitumor activity of spin labeled derivatives of podophyllotoxin. Life Sci Oxford 1997, 60, 511. <>
  • Wang Yan-guang, Pan Jian-lin, Shi Jian-feng, Chen* Yao-zu: NEW SPIN LABELED ANALOGUES OF PODOPHYLLOTOXIN AS POTENTIAL ANTITUMOR AGENTS. Life Sci Oxford 1997, 61, 537. <>
  • Lu Kuan-ke, Wang Yan-guang, Chen Yao-zu: Synthesis of Novel Spin Labeled Analogues of Podophyllotoxin Glycoside. Synth Common 1997, 27, 1963. <>
  • Dewynter Georges, Abdaoui Mohamed, Regainia Zine, Montero Jean-Louis: Synthesis of n-sulfamoyloxazolidinones and -perhydrooxazinones reactivity and use as donors in the transsulfamoylation reaction; application to the preparation of 2-chloroethylnitrososulfamides. IV. Tetrahedron 1996, 52, 14217. <>
  • Abdaoui Mohamed, Dewynter Georges, Aouf Nourredine, Favre Gilles, Morère Alain, Montero Jean-Louis: A new family of potential oncostatics: 2-chloroethylnitrososulfamides (CENS)—I. Synthesis, structure, and pharmacological evaluation (preliminary results). biorg med chem 1996, 4, 1227. <>
  • Abdaoui Mohamed, Dewynter Georges, Aouf Noureddine, Montero Jean-Louis: SYNTHESIS OF 2-CHLOROETHYLNITROSOSULFAMIDES (CENS) VIA A TRANSSULFAMOYLATION REACTION. Phosphorus Sulfur Silicon Relat Elem 1996, 118, 39. <>
  • Sosnovsky George, Lukszo Jan, Konieczny Maria, Purgstaller Klaus, Laib Frank: In the search for new anticancer drugs. 26. A comparison of anticancer activities of several tepa, thio-tepa, seleno-tepa, and azetidine analogs, including congeners containing an aminoxyl moiety. J Pharm Sci 1994, 83, 982. <>
  • Sosnovsky George, Gnewuch C. Thomas: In the search for new anticancer drugs. 27. Synthesis and comparison of anticancer activity in vivo of amino acids, carbohydrates, and carbohydrate-amino acid conjugates containing the [N′-(2-chloroethyl)-N′-nitrosoamino]carbonyl group. J Pharm Sci 1994, 83, 989. <>
  • Sosnovsky George, Baysal Mustafa, Erciyas Ercin: In the search for new anticancer drugs. 28. Synthesis and evaluation of highly active aminoxyl labeled amino acid derivatives containing the [N;-(2-chloroethyl)-N′-nitrosoamino]carbonyl group. J Pharm Sci 1994, 83, 999. <>
  • Subczynski Witold K., Wojas Jerzy, Wojas Jerzy, Wojas Jerzy, Pezeshk Vida, Pezeshk Abbas: Effects of probucol on phase transition and fluidity of phosphatidylcholine membranes: A spin label study. J  Inorg Biochem 1994, 55, 1. <>
  • Sosnovsky George, Prakash Indra, Rao Nuti Uma Maheswara: In the search for new anticancer drugs. XXIV: Synthesis and anticancer activity of amino acids and dipeptides containing the 2-chloroethyl- and [N′-(2-chloroethyl)-N′-nitroso]-aminocarbonyl groups. J Pharm Sci 1993, 82, 1. <>
  • Pezeshk Abbas, Pezeshk Vida, Firlej Alina, Wojas Jerzy, Subczynski Witold K.: Transport of spin-labeled tetracycline across model and biological membranes. Life Sci Oxford 1993, 52, 1071. <>
  • Pezeshk Abbas, Pezeshk Vida: Spectroscopic and biological studies of spin-labeled tetracycline. Life Sci Oxford 1992, 50, 1561. <>
  • Pezeshk Abbas, Pezeshk Vida, Wojas Jerzy, Subczynski Witold K., Subczynski Witold K.: Partitional and motional properties of a spin-labeled daunomycin in lipid bilayers. An ESR study. J  Inorg Biochem 1992, 46, 67. <>
  • Sosnovsky George, Rao Nuti Uma Maheshwara: In the search for new anticancer drugs. XXIII: Exploration of a predictive design for anticancer drugs of carbohydrates containingN-nitrosochloroethylamino,n-nitrosomethyl, andN-nitrosoaminoxyl components. J Pharm Sci 1991, 80, 693. <>